On November 2, 2025, the Indianapolis Colts are set to clash with the Pittsburgh Steelers at Acrisure Stadium in Pittsburgh. The kickoff is scheduled for 1:00 PM.

The Colts, who are top-ranked in their division and fourth in the conference, boast a record of 3-1-0, showcasing a robust winning percentage of 0.75. They have accumulated 123 points so far, against 83 allowed, resulting in a positive net point difference of 40.

On the other side, the Steelers hold an identical record of 3-1-0 but with a slight negative net point difference of -2, having scored 96 points and conceded 98. They rank first in their division and second in the conference.

In their recent outings, the Colts secured a win against Miami with a final score of 16-10 at Lucas Oil Stadium. They achieved 16 first downs and amassed 155 rushing yards and 129 passing yards. Anthony Richardson, the team’s quarterback, threw for 129 yards during the game, though he did not manage to score a touchdown, ending with a passer rating of 59.2.

The Steelers, meanwhile, triumphed over the New York Jets with a convincing 37-15 victory at home. They registered 21 first downs, along with 149 rushing yards and 260 passing yards. Russell Wilson led the way with 264 passing yards and 2 touchdowns, reflecting a high passer rating of 108.98.

Both quarterbacks are set to lead their teams again, promising a thrilling showdown. Richardson aims to boost his performance, while Wilson looks to maintain his high form.

As for the betting landscape, the Steelers are pegged as favorites with a point spread of -3.50, meaning they are expected to win by at least four points. Conversely, the Colts have a point spread of 3.50. The total points over/under for the game is set at 44.70, indicating expectations for a moderately high-scoring affair. In terms of the moneyline, the Steelers are favored with odds of -181, and the Colts stand at 151, suggesting a competitive battle ahead.

Sports enthusiasts and bettors alike can follow further updates and insights on betOhiosports.com.