The upcoming NFL clash between the Indianapolis Colts and the Los Angeles Chargers is scheduled to take place at SoFi Stadium in Inglewood on October 19, 2025, with an early kickoff set for 4:05 PM.

Last season, the Indianapolis Colts impressed by securing the top position in their division and fourth overall in their conference with a 3-1-0 record, achieving a .750 winning percentage. They successfully scored 123 points while conceding 83, resulting in a positive net point difference of 40.

Similarly, the Los Angeles Chargers matched their divisional rank and were just behind in the conference at third, also with a 3-1-0 standing and a .750 winning percentage. They accumulated 88 points and permitted 71, marking a net point difference of 17.

In their latest outings, the Colts eked out a 20-17 victory over Tennessee at Nissan Stadium, boasting 20 first downs, alongside 80 rushing and 189 passing yards. Conversely, the Chargers emerged victorious against Denver, 23-16, at Empower Field at Mile High, with 22 first downs, 128 rushing yards, and 222 passing yards.

Quarterback performance has been pivotal, with Colts’ Joe Flacco throwing for 189 yards and two touchdowns for a passer rating of 77.63, while Chargers’ Justin Herbert threw for 237 yards and one touchdown, boasting a passer rating of 92.4.

The betting odds highlight the Chargers as favorites with a point spread of -6.40, suggesting analysts believe in their ability to cover this margin. The Colts, with a point spread of +6.90, are viewed as underdogs, which might interest value-seeking bettors. The total points (over/under) for the game is set at 48.80, indicating expectations of a moderately high-scoring affair. Moneyline odds are -284 for the Chargers and +230 for the Colts, reflecting the perceived likelihood of each team’s victory.

This match-up promises to keep fans on the edge of their seats, considering the balanced strengths and recent performances of both teams.